Fwd: Body weight and vitamin D

An interesting article on vitamin d and weight loss. Not many patients
in the study, but an interesting association. Dr Evan

Vitamin D and risk of CVD in overweight and obese women
March 1, 2012 — John Cannell, MD

One of the most replicated findings in vitamin D research is that the higher
your vitamin D, the less you weigh; the lower your vitamin D, the more you
weigh. Conventional wisdom says that fat-soluble vitamins, like D, dissolve
themselves in fat and disappear from the blood.

Another explanation is even simpler: if you dissolve a teaspoon of sugar in
a glass of water, it will be sweeter than if you dissolve it in a quart of
water. That is, anything (vitamin D) dissolved in a limited mass (fat) will
be more concentrated.

Body weight and vitamin D blood levels

But what about the possibility of vitamin D playing a causative role, not
just an associative role, in obesity and body mass? That is, to a limited
extent, does vitamin D act like a diet pill? Last week, Dr. Selehpour of the
Tehran University of Medical Sciences found some interesting results in her
randomized controlled trial.

Salehpour A, Shidfar F, Hosseinpanah F, Vafa M, Razaghi M, Hoshiarrad A,
Gohari M. Vitamin D3 and the risk of CVD in overweight and obese women: a
randomised controlled trial. Br J Nutr. 2012 Feb 9:1-8. [Epub ahead of

In this RCT of 77 overweight women, they gave half a small dose of vitamin D
(1,000 IU/day), and half a placebo. In just 12 weeks, the vitamin D group
had lost five more pounds than the control group. They also found improved
scores in lipoprotein/cholesterol ratios for better heart health in the
vitamin D group verses the placebo. Which brings some readers to a question:
“If I want to diet, how much vitamin D should I take?”

First, 5,000 IU/day is for otherwise healthy adults weighing average adult
weight (125-200 pounds). If you’re above this weight, however, 32 IU per
pound per day is a good rule of thumb (as reported in the “Body weight and
vitamin D blood levels” blog above. This means that a 300lb person would
need 10,000 IU/day, though it wouldn’t surprise me if they needed more. Only
way to know is to test blood levels. As your weight decreases, it is
important to reduce your dose.

I doubt vitamin D is a classic diet pill. It may work by increasing your
activity as your “get up and go” is back. Just lying on the sofa popping
vitamin D pills will get you nowhere, however. Follow that urge to take the
walk, clean out the garage, and take that weekend trip.

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